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Mitochondrial carriers set the epigenetic age


New research reveals that the mitochondrial citrate carrier is crucial for the accumulation of acetyl-CoA in the cytosol and nucleus, and efficient histone acetylation. Lysosomal degradation of this carrier drives mesenchymal stem cell aging in a process characterized by tightly packed chromatin and reduced expression of osteogenic genes.

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Fig. 1: The levels of the mitochondrial citrate carrier determine nuclear gene expression patterns.


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Correspondence to Johannes M. Herrmann.

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Groh, C., Herrmann, J.M. Mitochondrial carriers set the epigenetic age. Nat Aging 1, 755–756 (2021).

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