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MICROBIOME

Young microbiota rejuvenates the aging brain

Nature Aging volume 1, pages 625–627 (2021)Cite this article

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The gut microbiota controls immunity and brain function, but its role in cognitive aging is unclear. Boehme et al. found that fecal microbiota transplantation from young into aged mice attenuated cognitive impairments and reversed differences in hippocampal metabolites, and some aspects of peripheral and brain immunity.

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Fig. 1: Fecal microbiota transplantation from yFMT to aged mice ameliorates aging-associated immune and neurocognitive impairments.

References

  1. Fung, T. C., Olson, C. A. & Hsiao, E. Y. Nat. Neurosci. 20, 145–155 (2017).

    Article  CAS  Google Scholar 

  2. Kim, S. & Jazwinski, S. M. Gerontology 64, 513–520 (2018).

    Article  CAS  Google Scholar 

  3. Claesson, M. J. et al. Nature 488, 178–184 (2012).

    Article  CAS  Google Scholar 

  4. Boehme, M. et al. Nat. Aging https://doi.org/10.1038/s43587-021-00093-9 (2021).

  5. Bartsch, T. & Wulff, P. Neuroscience 309, 1–16 (2015).

    Article  CAS  Google Scholar 

  6. Tay, T. L., Savage, J. C., Hui, C. W., Bisht, K. & Tremblay, M. E. J. Physiol. 595, 1929–1945 (2017).

    Article  CAS  Google Scholar 

  7. Erny, D. et al. Nat. Neurosci. 18, 965–977 (2015).

    Article  CAS  Google Scholar 

  8. Painter, M. M. et al. Mol. Neurodegener. 10, 43 (2015).

    Article  CAS  Google Scholar 

  9. Luscombe, V. B., Lucy, D., Bataille, C. J. R., Russell, A. J. & Greaves, D. R. DNA Cell Biol. 39, 1926–1937 (2020).

    Article  CAS  Google Scholar 

  10. Grabert, K. et al. Nat. Neurosci. 19, 504–516 (2016).

    Article  CAS  Google Scholar 

  11. Biyong, E. F. et al. Int. J. Obes. (Lond.) 45, 588–598 (2021).

    Article  CAS  Google Scholar 

  12. Hellwig, S. & Domschke, K. Gerontology 65, 465–473 (2019).

    Article  CAS  Google Scholar 

  13. Gonzalez-Santana, A. & Diaz Heijtz, R. Trends Mol. Med. 26, 729–743 (2020).

    Article  CAS  Google Scholar 

  14. Jaggar, M., Rea, K., Spichak, S., Dinan, T. G. & Cryan, J. F. Front. Neuroendocrinol. 56, 100815 (2020).

    Article  Google Scholar 

  15. Levine, D. A. et al. JAMA Netw. Open 4, e210169 (2021).

    Article  Google Scholar 

Download references

Acknowledgements

The Diaz Heijtz Laboratory is supported by grants from the Swedish Research Council, the Swedish Brain Foundation, the Olle Engkvist Byggmästare Foundation, the Frimurare Barnhus and the European Community (SmartAge project). Work in the group of J.L. is supported by the Dutch MS Research Foundation and the Zabawas Foundation.

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Authors and Affiliations

  1. Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden

    Rochellys Diaz Heijtz & Ayoze Gonzalez-Santana

  2. Institut National de la Santé et de la Recherche Médicale (INSERM) Unit 1239, University of Rouen Normandy, Rouen, France

    Rochellys Diaz Heijtz

  3. Department of Pathology and Medical Biology, University Medical Center Groningen (UMCG), Groningen, the Netherlands

    Jon D. Laman

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  1. Rochellys Diaz Heijtz
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  2. Ayoze Gonzalez-Santana
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Correspondence to Rochellys Diaz Heijtz.

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Heijtz, R.D., Gonzalez-Santana, A. & Laman, J.D. Young microbiota rejuvenates the aging brain. Nat Aging 1, 625–627 (2021). https://doi.org/10.1038/s43587-021-00100-z

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