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INFLAMMAGING

The quest for long non-coding RNAs involved in aging

Nature Aging volume 1, pages 418–419 (2021)Cite this article

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Chronic inflammation, or ‘inflammaging’, is a key process in age-related diseases, and identification of the molecular players involved is a top priority. Cai and Han identified an evolutionary conserved functional lncRNA able to modulate the release of inflammatory SASP molecules from senescent cells through the NF-κB pathway.

Accumulation of senescent cells during aging leads to a chronic state of inflammation known as ‘inflammaging’, resulting from the release of senescence associated secretory phenotype (SASP) molecules. In this issue, Cai and Han1 use comparative genomics and other approaches to investigate if specific non-coding transcripts play a role in SASP regulation, and they identify a family of evolutionary conserved nuclear factor (NF)-κB-modulating aging-related long non-coding RNAs (NFKBMARL).

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Fig. 1: Cai and Han found that the evolutionary conserved lncRNA NFΚBMARL-1 modulates the release of SASP molecules from senescent cells through the NF-κB pathway.

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Acknowledgements

The authors acknowledge support from European Research Council (RIBOMYLOME_309545 and ASTRA_855923) and the Horizon 2020 projects (IASIS_727658 and INFORE_825080).

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Authors and Affiliations

  1. Department of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, Naples, Italy

    Rosario Avolio

  2. Center for Human Technology, Istituto Italiano di Tecnologia, Genoa, Italy

    Elias Bechara & Gian Gaetano Tartaglia

  3. Department of Biology and Biotechnology Charles Darwin, Sapienza University of Rome, Rome, Italy

    Gian Gaetano Tartaglia

  4. Center for Life Nano- & Neuro-Science, Istituto Italiano di Tecnologia, Rome, Italy

    Gian Gaetano Tartaglia

  5. Institucio Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain

    Gian Gaetano Tartaglia

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  1. Rosario Avolio
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  2. Elias Bechara
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  3. Gian Gaetano Tartaglia
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Correspondence to Gian Gaetano Tartaglia.

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Avolio, R., Bechara, E. & Tartaglia, G.G. The quest for long non-coding RNAs involved in aging. Nat Aging 1, 418–419 (2021). https://doi.org/10.1038/s43587-021-00069-9

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