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The quest for long non-coding RNAs involved in aging

Chronic inflammation, or ‘inflammaging’, is a key process in age-related diseases, and identification of the molecular players involved is a top priority. Cai and Han identified an evolutionary conserved functional lncRNA able to modulate the release of inflammatory SASP molecules from senescent cells through the NF-κB pathway.

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Fig. 1: Cai and Han found that the evolutionary conserved lncRNA NFΚBMARL-1 modulates the release of SASP molecules from senescent cells through the NF-κB pathway.


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The authors acknowledge support from European Research Council (RIBOMYLOME_309545 and ASTRA_855923) and the Horizon 2020 projects (IASIS_727658 and INFORE_825080).

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Correspondence to Gian Gaetano Tartaglia.

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Avolio, R., Bechara, E. & Tartaglia, G.G. The quest for long non-coding RNAs involved in aging. Nat Aging 1, 418–419 (2021).

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