The tumor microenvironment (TME) impacts different phases of tumor progression and therapy resistance. Zhang et al. show that senescent stromal cells activate an epigenetic program that controls the senescence-associated secretory phenotype and can be targeted to boost responses to chemotherapy.
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Desbats, M.A., Zumerle, S. & Alimonti, A. Epiregulation of the SASP makes good neighbors. Nat Aging 1, 420–421 (2021). https://doi.org/10.1038/s43587-021-00068-w
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DOI: https://doi.org/10.1038/s43587-021-00068-w
