Using mouse models of osteoarthritis (OA), a new study finds that osteoclasts secrete exosomes that deliver miRNAs to chondrocytes, leading to an increase in metalloproteinase activity in cartilage. A bone-specific inhibitor of exosome production can halt this process, hinting at a new therapeutic strategy for patients with OA.
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D.M.P. is the co-founder and chief scientist at exBiome BV, advisor of Takeda and receives research funding from Prediction Biosciences. All other authors declare no competing interests.
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Meulenbelt, I., Ramos, Y.F.M., Baglio, S.R. et al. Censoring exosomal crosstalk in osteoarthritis. Nat Aging 1, 332–334 (2021). https://doi.org/10.1038/s43587-021-00052-4