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Censoring exosomal crosstalk in osteoarthritis

Using mouse models of osteoarthritis (OA), a new study finds that osteoclasts secrete exosomes that deliver miRNAs to chondrocytes, leading to an increase in metalloproteinase activity in cartilage. A bone-specific inhibitor of exosome production can halt this process, hinting at a new therapeutic strategy for patients with OA.

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Fig. 1: Mechanisms and potential clinical implications of exosomal crosstalk in OA.

References

  1. Woolf, A. D., Erwin, J. & March, L. Best Pract. Res. Cl. Rh. 26, 183–224 (2012).

    Article  Google Scholar 

  2. Liu, J. et al. Nat. Aging https://doi.org/10.1038/s43587-021-00050-6 (2021).

  3. Sun, W. et al. Cell Discov. 2, 16015 (2016).

    Article  CAS  Google Scholar 

  4. Pegtel, D. M. et al. Proc. Natl Acad. Sci. USA 107, 6328–6333 (2010).

    Article  CAS  Google Scholar 

  5. Lotz, M. et al. Ann. Rheum. Dis. 72, 1756–1763 (2013).

    Article  CAS  Google Scholar 

  6. Coutinho de Almeida, R. et al. Rheumatology https://doi.org/10.1093/rheumatology/keaa391 (2020).

  7. Coates, L. C. et al. Arthritis Rheumatol. https://doi.org/10.1002/art.41716 (2021).

  8. den Hollander, W. et al. Arthritis Rheumatol. 67, 2108–2116 (2015).

    Article  CAS  Google Scholar 

  9. Coutinho de Almeida, R. et al. Ann. Rheum. Dis. 78, 270–277 (2019).

    Article  Google Scholar 

  10. van Hoolwerff, M. et al. Arthritis Rheumatol. 72, 1845–1854 (2020).

    Article  CAS  Google Scholar 

  11. Pegtel, D. M. M. & Gould, S. J. S. J. Annu. Rev. Biochem. 88, 487–514 (2019).

    Article  CAS  Google Scholar 

  12. Tavallaee, G., Rockel, J. S., Lively, S. & Kapoor, M. Front. Med. 7, 376 (2020).

    Article  Google Scholar 

  13. Ramos, Y. F. et al. Osteoarthr. Cartil. 27, S69 (2019).

    Article  Google Scholar 

  14. Ali, S. A. et al. Osteoarthr. Cartil. 28, 1471–1481 (2020).

    Article  CAS  Google Scholar 

  15. Beyer, C. et al. Ann. Rheum. Dis. 74, e18 (2015).

    Article  Google Scholar 

Download references

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Correspondence to Ingrid Meulenbelt or D. Michiel Pegtel.

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D.M.P. is the co-founder and chief scientist at exBiome BV, advisor of Takeda and receives research funding from Prediction Biosciences. All other authors declare no competing interests.

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Meulenbelt, I., Ramos, Y.F.M., Baglio, S.R. et al. Censoring exosomal crosstalk in osteoarthritis. Nat Aging 1, 332–334 (2021). https://doi.org/10.1038/s43587-021-00052-4

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