Chimeric antigen receptor (CAR) T cells are effective for the treatment of therapy-resistant blood cancers but not solid tumors. We used a well-studied mutant c-KIT protein (c-KIT D816V) as a co-stimulatory domain to generate CAR T cells with strong IFNγ signaling that were able to overcome the immunosuppressive microenvironment of solid tumors.
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This is a summary of: Adusumilli, P. S. et al. c-Kit signaling potentiates CAR T cell efficacy in solid tumors by CD28- and IL-2-independent co-stimulation. Nat. Cancer https://doi.org/10.1038/s43018-023-00573-4 (2023).
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A co-stimulatory domain increases CAR T cell therapy efficacy in mice with solid tumors. Nat Cancer 4, 935–936 (2023). https://doi.org/10.1038/s43018-023-00574-3