Glioblastomas have limited treatment options and dire prognoses. A study now shows that GAP43-mediated transfer of functional mitochondria from astrocytes to glioblastoma cells leads to metabolism, signaling and epigenome remodeling that favor tumor growth, thus highlighting GAP43 inhibition as a promising therapeutic strategy for glioblastoma.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 digital issues and online access to articles
$119.00 per year
only $9.92 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Giacomello, M., Pyakurel, A., Glytsou, C. & Scorrano, L. Nat. Rev. Mol. Cell Biol. 21, 204–224 (2020).
Dong, W. et al. Cell Mol. Neurobiol. https://doi.org/10.1007/s10571-023-01331-x (2023).
Shen, J. et al. Cell Death Dis. 9, 81 (2018).
Islam, M. N. et al. Nat. Med. 18, 759–765 (2012).
Dong, L. F. et al. eLife 6, e22187 (2017).
Tan, A. S. et al. Cell Metab. 21, 81–94 (2015).
Zampieri, L. X., Silva-Almeida, C., Rondeau, J. D. & Sonveaux, P. Int. J. Mol. Sci. 22 (2021).
Watson, D. C. Nat. Cancer https://doi.org/10.1038/s43018-023-00556-5 (2023).
Batash, R., Asna, N., Schaffer, P., Francis, N. & Schaffer, M. Curr. Med. Chem. 24, 3002–3009 (2017).
Burster, T. et al. Front Cell. Dev. Biol. 9, 695325 (2021).
Osswald, M. et al. Nature 528, 93–98 (2015).
Pinto, G. et al. Biochem. J. 478, 21–39 (2021).
Salaud, C. et al. Biochem. Biophys. Res. Commun. 533, 139–147 (2020).
Pinto, G., Brou, C. & Zurzolo, C. Trends Cancer 6, 874–888 (2020).
Hayakawa, K. et al. Nature 535, 551–555 (2016).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing inerests.
Rights and permissions
About this article
Cite this article
Semenzato, M., Scorrano, L. Mind the GAP(43) for mitochondria transfer to glioblastomas. Nat Cancer 4, 588–589 (2023). https://doi.org/10.1038/s43018-023-00564-5
Published:
Issue Date:
DOI: https://doi.org/10.1038/s43018-023-00564-5
