An antisense RNA, NQO1-AS, binds and stabilizes its sense strand, upregulating the redox enzyme NQO1 in metastatic breast cancer cells. Overexpression of NQO1 facilitates lung colonization by suppressing oxidative stress and ferroptosis, and cancer cells dependent on this pathway can be targeted by a combined therapy that induces ferroptosis while simultaneously inhibiting NQO1.
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Ozsolak, F. et al. Comprehensive polyadenylation site maps in yeast and human reveal pervasive alternative polyadenylation. Cell 143, 1018–1029 (2010). A map of polyadenylation sites in yeast and human cells suggests a regulatory role for antisense RNAs.
Minn, A. J. et al. Genes that mediate breast cancer metastasis to lung. Nature 436, 518–524 (2005). This paper presents a model of breast cancer metastasis to the lung via in vivo selection of an established breast cancer cell line.
Ross, D. Quinone reductases multitasking in the metabolic world. Drug Metab. Rev. 36, 639–654 (2004). A review article describing the metabolic roles of NQO1.
Dixon, S. J. & Stockwell, B. R. The hallmarks of ferroptosis. Annu. Rev. Cancer Biol. 3, 35–54 (2019). A review article describing ferroptosis as a promising therapeutic target in cancer.
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This is a summary of: Culbertson, B. et al. A sense-antisense RNA interaction promotes breast cancer metastasis via regulation of NQO1 expression. Nat. Cancer https://doi.org/10.1038/s43018-023-00554-7 (2023).
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An antisense RNA promotes breast cancer metastasis via upregulation of NQO1. Nat Cancer 4, 592–593 (2023). https://doi.org/10.1038/s43018-023-00555-6