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Biomolecular condensates

Biocondensates fuel tumor immune evasion

Nature Cancer volume 4, pages 312–314 (2023)Cite this article

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Transactivation hubs and related biomolecular condensates are emerging as relevant molecular players in cancer biology. A new study now links PD-L1 upregulation on the cancer cell surface and IRF1–KAT8 transactivation hubs at PD-L1 loci. Therapeutic targeting of these hubs holds potential to unleash antitumor immunity.

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Fig. 1: IRF1–KAT8 biocondensates upregulate PD-L1 expression and their disruption promotes antitumor immunity.

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Authors and Affiliations

  1. Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA

    Kelsey P. Kubelick & Felipe Garcia Quiroz

  2. School of Electrical and Computer Engineering, Georgia Institute of Technology, Atlanta, GA, USA

    Kelsey P. Kubelick

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  1. Kelsey P. Kubelick
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  2. Felipe Garcia Quiroz
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Correspondence to Felipe Garcia Quiroz.

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The authors declare no competing interests.

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Kubelick, K.P., Quiroz, F.G. Biocondensates fuel tumor immune evasion. Nat Cancer 4, 312–314 (2023). https://doi.org/10.1038/s43018-023-00520-3

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