Using an unbiased algorithm based on kinase–phosphorylation site interactions that is applicable to any proteomic dataset, we identified and experimentally validated two protein kinases (PKCδ and DNA-PKcs) as the master kinases that drive two functional subtypes of glioblastoma multiforme and are potential therapeutic targets of other cancer subtypes.
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This is a summary of: Migliozzi, S. et al. Integrative multi-omics networks identify PKCδ and DNA-PK as master kinases of glioblastoma subtypes and guide targeted cancer therapy. Nat. Cancer https://doi.org/10.1038/s43018-022-00510-x (2023).
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Master kinases extracted from proteogenomic networks in glioblastoma drive cancer subtypes. Nat Cancer 4, 159–160 (2023). https://doi.org/10.1038/s43018-022-00511-w
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DOI: https://doi.org/10.1038/s43018-022-00511-w
