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Therapy resistance

JAK inhibition shows two faces in prostate cancer

Therapeutic resistance in prostate cancer can be driven by lineage plasticity, but the mechanisms behind this are unclear, and therapies to prevent or reverse the process are nonexistent. A new study reveals the JAK/STAT signaling axis as a driver of lineage plasticity with tremendous therapeutic potential.

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Fig. 1: JAK/STAT signaling and lineage plasticity.


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Correspondence to Christopher E. Barbieri.

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Brady, N.J., Barbieri, C.E. JAK inhibition shows two faces in prostate cancer. Nat Cancer 3, 1021–1023 (2022).

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