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Genome integrity

An RNA link for METTL16 and DNA repair in PDAC

Increasing evidence links RNA methyltransferases to DNA damage repair. METTL16 is now shown to antagonize homologous recombination by preventing DNA-end resection via MRE11. Thus, METTL16 may represent a cancer vulnerability that can be used to identify patients able to benefit from combination therapies with DNA-damaging agents.

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Fig. 1: PDAC tumors with high METTL16 are deficient in DNA repair and more sensitive to combination therapy.

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Correspondence to Claudio R. Alarcón.

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Perez-Pepe, M., Alarcón, C.R. An RNA link for METTL16 and DNA repair in PDAC. Nat Cancer 3, 1018–1020 (2022). https://doi.org/10.1038/s43018-022-00434-6

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