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CANCER GENOMICS

Form follows function in cancer genomes

Structural variants (SVs), such as copy-number alterations, rearrangements and aneuploidies, are common somatic changes in cancer genomes and rich sources of driver oncogenes, but reconstructing these from sequencing data is a challenge. Two new studies shed light on the diversity and importance of the SV landscape in cancer.

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Fig. 1: Signatures of complex rearrangements.

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Correspondence to Paul S. Mischel or Vineet Bafna.

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P.S.M. is a co-founder and Scientific Advisory Board member and has equity interest in Boundless Bio. V.B. is a co-founder, consultant and Scientific Advisory Board member and has equity interest in Boundless Bio and Abterra. P.S.M. is team lead of and V.B. is a member of the Cancer Grand Challenges eDyNAmiC team.

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Mischel, P.S., Bafna, V. Form follows function in cancer genomes. Nat Cancer 3, 905–906 (2022). https://doi.org/10.1038/s43018-022-00428-4

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