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Colorectal cancer cells expressing Mex3a drive recurrence after chemotherapy

Many patients with colorectal cancer (CRC) relapse after chemotherapy. Tumor cells that do not completely adapt to their environment (owing to an incomplete set of CRC driver mutations) enter a latent state, in which the expression of Mex3a is upregulated. Mex3a+ cells are chemoresistant and reactivate after treatment, which leads to regeneration of the disease.

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Fig. 1: Lineage-tracing analysis of Mex3a+ cells in CRC mouse organoids during chemotherapy.


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This is a summary of: Batlle, E. et al. Mex3a marks drug-tolerant persister colorectal cancer cells that mediate relapse after chemotherapy. Nat. Cancer (2022).

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Colorectal cancer cells expressing Mex3a drive recurrence after chemotherapy. Nat Cancer 3, 1024–1025 (2022).

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