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PARP11 interfer(on)es with CAR T cell efficacy

Despite the remarkable success of chimeric antigen receptor (CAR) T cell therapies in the treatment of hematological malignancies, this strategy remains challenging in solid tumors. One major obstacle is the hostile immunosuppressive tumor microenvironment. New research demonstrates that targeting PARP11 can overcome this immunosuppression and boost CAR T cell efficacy through stabilization of IFNAR1.

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Fig. 1: T cell immunosuppression induced by the adenosine–PARP11–IFNAR1 pathway.


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P.A.B. is supported by a Victorian Cancer Agency Mid-Career Fellowship (MCRF20011).

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Correspondence to Paul A. Beavis.

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Munoz, I., Beavis, P.A. PARP11 interfer(on)es with CAR T cell efficacy. Nat Cancer 3, 790–792 (2022).

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