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TUMOR IMMUNOLOGY

γδ T cells share the spotlight in cancer

Nature Cancer volume 3, pages 657–658 (2022)Cite this article

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The phenotypes of γδ T cells infiltrating human tumors and their role in anti-tumor immunity remain poorly understood. A new study demonstrates that Vδ1 lymphocytes with cytolytic potential and features of tissue-resident-memory differentiation are predictive of survival in patients with non–small-cell lung cancer.

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Fig. 1: Lung-resident memory Vδ1 T cells exert clinically relevant immune pressure against lung cancer progression.

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Authors and Affiliations

  1. Department of Immunology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA

    Jose R. Conejo-Garcia & Patrick Innamarato

  2. Department of Gynecologic Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA

    Jose R. Conejo-Garcia

  3. Department of Malignant Hematology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA

    Jose R. Conejo-Garcia

Authors
  1. Jose R. Conejo-Garcia
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  2. Patrick Innamarato
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Correspondence to Jose R. Conejo-Garcia.

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Competing interests

J.R.C.-G. has stock options in Compass Therapeutics, Anixa Biosciences and Alloy Therapeutics; conducts sponsored research for Anixa Biosciences; receives honoraria from Alloy Therapeutics and Leidos; and has intellectual property with Compass Therapeutics and Anixa Biosciences.

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Conejo-Garcia, J.R., Innamarato, P. γδ T cells share the spotlight in cancer. Nat Cancer 3, 657–658 (2022). https://doi.org/10.1038/s43018-022-00396-9

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