Acute myeloid leukemia (AML) is characterized by distinct genetic and molecular alterations, including rearrangements in the mixed lineage leukemia (MLL) gene. A study now presents a therapeutic strategy for MLL-rearranged (MLL-r) AML that exploits a unique co-dependency on IKAROS and MENIN.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 digital issues and online access to articles
$119.00 per year
only $9.92 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Winters, A. C. & Bernt, K. M. Front. Pediatr. 5, 4 (2017).
Krivtsov, A. V. et al. Cancer Cell 36, 660–673 e611 (2019).
Falini, B. et al. Blood 137, 589–599 (2021).
Jones, L. M. et al. Paediatr. Drugs 23, 485–497 (2021).
Conneely, S. E. & Rau, R. E. Cancer Metastasis Rev. 39, 189–209 (2020).
Kayser, S. & Levis, M. J. Br. J. Haematol. 180, 484–500 (2018).
Aubrey, B. J. et al. Nat. Cancer https://doi.org/10.1038/s43018-022-00366-1 (2022).
Stein, E. M. et al. Blood 131, 2661–2669 (2018).
Krönke, J. et al. Science 343, 301–305 (2014).
Faber, J. et al. Blood 113, 2375–2385 (2009).
Zeisig, B. B. et al. Mol. Cell Biol. 24, 617–628 (2004).
Brunetti, L. et al. Cancer Cell 34, 499–512.e499 (2018).
Kotla, V. et al. J. Hematol. Oncol. 2, 36 (2009).
Fang, J. et al. Nat. Med. 22, 727–734 (2016).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing interests.
Rights and permissions
About this article
Cite this article
Jones, L.M., Starczynowski, D.T. IKAROS and MENIN in synergy in AML. Nat Cancer 3, 528–529 (2022). https://doi.org/10.1038/s43018-022-00387-w
Published:
Issue Date:
DOI: https://doi.org/10.1038/s43018-022-00387-w
