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CANCER THERAPY

IKAROS and MENIN in synergy in AML

Acute myeloid leukemia (AML) is characterized by distinct genetic and molecular alterations, including rearrangements in the mixed lineage leukemia (MLL) gene. A study now presents a therapeutic strategy for MLL-rearranged (MLL-r) AML that exploits a unique co-dependency on IKAROS and MENIN.

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Fig. 1: IKAROS and MENIN exhibit chromatin co-occupancy with MLL1, thereby impacting transcriptional regulation of MLL-r and NPM1c AML.

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Correspondence to Daniel T. Starczynowski.

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Jones, L.M., Starczynowski, D.T. IKAROS and MENIN in synergy in AML. Nat Cancer 3, 528–529 (2022). https://doi.org/10.1038/s43018-022-00387-w

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