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There are gremlins in prostate cancer

The lethality of prostate cancer is driven by its progression to a castration-resistant state. A new study identifies gremlin 1 (GREM1) as an agonist of fibroblast growth factor receptor 1 (FGFR1) that drives such progression when androgen receptor (AR) signaling is low, nominating GREM1 as a therapeutic target for prostate cancer with low AR activity.

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Fig. 1: GREM1 activity in castration-resistant prostate cancer.


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Correspondence to W. Nathaniel Brennen or John T. Isaacs.

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Sena, L.A., Brennen, W.N. & Isaacs, J.T. There are gremlins in prostate cancer. Nat Cancer 3, 530–531 (2022).

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