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Resistance is futile with fourth-generation EGFR inhibitors

Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors have revolutionized the treatment of EGFR-mutant non-small cell lung cancer; however, secondary resistance limits their efficacy, emphasizing the need for newer approaches. A study now shows preclinical development of allosteric EGFR inhibitors that overcome acquired therapy resistance.

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Fig. 1: Mechanisms of resistance to allosteric EGFR inhibitors.


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Correspondence to Sandra Misale.

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S.M. has served as a consultant for Boehringer Ingelheim. M.M. declares no competing interests.

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Marasco, M., Misale, S. Resistance is futile with fourth-generation EGFR inhibitors. Nat Cancer 3, 381–383 (2022).

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