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METASTASIS

Radiation sparks a dark side in neutrophils

Neutrophils may obtain either pro- or anti-tumorigenic phenotypes depending on environmental cues. A new study reports that cancer radiotherapy induces a neutrophilic response associated with tissue repair and leads to enhanced metastatic spread, highlighting a mechanism by which neutrophils promote metastatic tumor growth.

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Fig. 1: Irradiation stimulates a neutrophilic response that leads to enhanced metastatic propensity.

Amina Jbara.

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Correspondence to Zvi Granot.

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Heinberg, A., Granot, Z. Radiation sparks a dark side in neutrophils. Nat Cancer 3, 136–137 (2022). https://doi.org/10.1038/s43018-021-00324-3

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