Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

METASTASIS

Radiation sparks a dark side in neutrophils

Neutrophils may obtain either pro- or anti-tumorigenic phenotypes depending on environmental cues. A new study reports that cancer radiotherapy induces a neutrophilic response associated with tissue repair and leads to enhanced metastatic spread, highlighting a mechanism by which neutrophils promote metastatic tumor growth.

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Irradiation stimulates a neutrophilic response that leads to enhanced metastatic propensity.

Amina Jbara.

References

  1. Coffelt, S. B., Wellenstein, M. D. & de Visser, K. E. Nat. Rev. Cancer 16, 431–446 (2016).

    Article  CAS  Google Scholar 

  2. Fridlender, Z. G. et al. Cancer Cell 16, 183–194 (2009).

    Article  CAS  Google Scholar 

  3. Granot, Z. et al. Cancer Cell 20, 300–314 (2011).

    Article  CAS  Google Scholar 

  4. Sagiv, J. Y. et al. Cell Rep. 10, 562–573 (2015).

    Article  CAS  Google Scholar 

  5. Hedrick, C. C. & Malanchi, I. Nat. Rev. Immunol. https://doi.org/10.1038/s41577-021-00571-6 (2021).

  6. Jaillon, S. et al. Nat. Rev. Cancer 20, 485–503 (2020).

    Article  CAS  Google Scholar 

  7. Nolan, E. B. V. et al. Nat. Cancer https://doi.org/10.1038/s43018-022-00336-7 (2022).

  8. Peiseler, M. & Kubes, P. J. Clin. Invest. 129, 2629–2639 (2019).

    Article  Google Scholar 

  9. Kuonen, F., Secondini, C. & Ruegg, C. Clin. Cancer Res. 18, 5196–5202 (2012).

    Article  CAS  Google Scholar 

  10. Johnson, J. L. et al. J. Biol. Chem. 291, 25965–25982 (2016).

    Article  CAS  Google Scholar 

  11. Dvorak, H. F. N. Engl. J. Med. 315, 1650–1659 (1986).

    Article  CAS  Google Scholar 

  12. Granot, Z. Front. Immunol. 10, 1710–1715 (2019).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Zvi Granot.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Heinberg, A., Granot, Z. Radiation sparks a dark side in neutrophils. Nat Cancer 3, 136–137 (2022). https://doi.org/10.1038/s43018-021-00324-3

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s43018-021-00324-3

Search

Quick links

Nature Briefing: Cancer

Sign up for the Nature Briefing: Cancer newsletter — what matters in cancer research, free to your inbox weekly.

Get what matters in cancer research, free to your inbox weekly. Sign up for Nature Briefing: Cancer