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Pulling the strings of tumor collagen

The architecture of tumor collagen greatly influences tumor biology and therapeutic response. Two new studies identify tumor DDR1 as a central player in stromal collagen deposition and organization in the primary tumor and in disseminated tumor cells, resulting in immune exclusion or sustained dormancy, respectively.

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Fig. 1: A central role for tumor DDR1 in organizing stromal collagen architecture.


  1. Zunder, S. M. et al. Crit. Rev. Oncol. Hematol. 151, 102907 (2020).

    Article  Google Scholar 

  2. Brett, E. A. et al. Cancer Metab. 8, 14 (2020).

    Article  Google Scholar 

  3. Di Martino, J. S. N. et al. Nat. Cancer (2021).

    Article  PubMed  PubMed Central  Google Scholar 

  4. Sun, X. et al. Nature (2021).

    Article  PubMed  PubMed Central  Google Scholar 

  5. Santos-de-Frutos, K. & Djouder, N. Commun. Biol. 4, 747 (2021).

    Article  Google Scholar 

  6. Linde, N., Fluegen, G. & Aguirre-Ghiso, J. A. Adv. Cancer Res. 132, 45–71 (2016).

    Article  CAS  Google Scholar 

  7. Valiathan, R. R. et al. Cancer Metastasis Rev. 31, 295–321 (2012).

    Article  CAS  Google Scholar 

  8. Gao, H. et al. Cell 166, 47–62 (2016).

    Article  CAS  Google Scholar 

  9. Gruosso, T. et al. J. Clin. Invest. 129, 1785–1800 (2019).

    Article  Google Scholar 

  10. Vogel, W. F. FEBS Lett. 514, 175–180 (2002).

    Article  CAS  Google Scholar 

  11. Ray, A. & Provenzano, P. P. Curr. Opin. Cell Biol. 72, 63–71 (2021).

    Article  CAS  Google Scholar 

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Correspondence to Birgit Leitinger.

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Leitinger, B. Pulling the strings of tumor collagen. Nat Cancer 3, 9–10 (2022).

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