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METASTASIS

Keeping brain metastases dormant

Nature Cancer volume 3, pages 3–5 (2022)Cite this article

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A potential translational strategy to treat brain metastases is the induction or maintenance of proliferative dormancy in tumor cells. A new study shows that dormancy in breast cancer brain metastasis is maintained in the perivascular niche by astrocyte endfoot secretion of laminin-211, causing tumor cell membrane sequestration of YAP.

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Fig. 1: Mechanistic model of brain-specific metastatic dormancy.

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Authors and Affiliations

  1. Women’s Malignancies Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA

    Imran Khan & Patricia S. Steeg

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  1. Imran Khan
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  2. Patricia S. Steeg
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Correspondence to Patricia S. Steeg.

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The authors declare no competing interests.

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Khan, I., Steeg, P.S. Keeping brain metastases dormant. Nat Cancer 3, 3–5 (2022). https://doi.org/10.1038/s43018-021-00321-6

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