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CANCER BIOLOGY

A key malignant switch in skin SCC

The mechanisms regulating the progression of benign tumors to malignant carcinomas remain incompletely understood. A new study identifies the transcription factor NR2F2 as a specific regulator of this transition that plays critical roles in the maintenance of the malignant tumor state.

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Fig. 1: The transcription factor NR2F2 drives malignant transformation in carcinogen-induced and genetic mouse models of SCC.

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Correspondence to Nick Barker.

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Lim, H.Y.G., Barker, N. A key malignant switch in skin SCC. Nat Cancer 2, 1116–1118 (2021). https://doi.org/10.1038/s43018-021-00278-6

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