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CANCER IMMUNOTHERAPY

Splitting signals drives CARs further

CAR T cell therapies have made great strides in the clinic; however, multiple hurdles limit the efficacy of this approach for solid tumors. A new study has developed an optimized, dual-targeting CAR T cell that overcomes several of these challenges by enhancing T cell persistence and reducing therapy escape due to antigen loss.

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Fig. 1: Dual CAR expression with split co-stimulation and a shared CD3ζ domain enhances CAR activity.

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Correspondence to Avery D. Posey Jr..

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King-Peoples, T.R., Posey, A.D. Splitting signals drives CARs further. Nat Cancer 2, 873–875 (2021). https://doi.org/10.1038/s43018-021-00257-x

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