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CANCER THERAPY

A therapy PUSh for GBM

Pseudouridine is the most abundant RNA modification, but its biological role remains poorly understood. A study now finds dysregulated pseudouridine synthase PUS7 in glioblastoma and demonstrates that pharmacological inhibition of PUS7 leads to reduced tumorigenesis, which underpins the therapeutic potential of targeting epitranscriptomic regulators in cancer.

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Fig. 1: Pharmacological or genetic modulation of PUS7’s activity prevents GBM tumorigenesis.

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Correspondence to Sandra Blanco.

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Morón-Calvente, V., Blanco, S. A therapy PUSh for GBM. Nat Cancer 2, 876–878 (2021). https://doi.org/10.1038/s43018-021-00255-z

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