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Behind the IL-8 ball in prostate cancer

Prostate cancer is largely unresponsive to immunotherapy. A new study finds elevated expression of the chemokine IL-8, or its mouse homolog Cxcl15, in prostate cancer after castration, which leads to the recruitment of immunosuppressive myeloid cells. Blocking tumor infiltration with these cells could improve the response to immune-checkpoint inhibition and androgen-deprivation therapy.

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Fig. 1: Castration increases the recruitment of immunosuppressive myeloid cells to the prostate TME via IL-8.


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Correspondence to Ravi A. Madan or Claudia Palena.

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Madan, R.A., Palena, C. Behind the IL-8 ball in prostate cancer. Nat Cancer 2, 775–776 (2021).

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