Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

IMMUNOTHERAPY

Behind the IL-8 ball in prostate cancer

Nature Cancer volume 2, pages 775–776 (2021)Cite this article

Subjects

Prostate cancer is largely unresponsive to immunotherapy. A new study finds elevated expression of the chemokine IL-8, or its mouse homolog Cxcl15, in prostate cancer after castration, which leads to the recruitment of immunosuppressive myeloid cells. Blocking tumor infiltration with these cells could improve the response to immune-checkpoint inhibition and androgen-deprivation therapy.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on SpringerLink
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Castration increases the recruitment of immunosuppressive myeloid cells to the prostate TME via IL-8.

References

  1. Lopez-Bujanda, Z.A. et al. Nat. Cancer https://doi.org/10.1038/s43018-021-00227-3 (2021).

  2. Fousek, K., Horn, L. A. & Palena, C. Pharmacol. Ther. 219, 107692 (2021).

    Article  CAS  Google Scholar 

  3. Schalper, K. A. et al. Nat. Med. 26, 688–692 (2020).

    Article  CAS  Google Scholar 

  4. Yuen, K. C. et al. Nat. Med. 26, 693–698 (2020).

    Article  CAS  Google Scholar 

  5. Dominguez, C., McCampbell, K. K., David, J. M. & Palena, C. JCI Insight 2, e94296 (2017).

    Article  Google Scholar 

  6. Mercader, M. et al. Proc. Natl Acad. Sci. USA 98, 14565–14570 (2001).

    Article  CAS  Google Scholar 

  7. Morse, M. D. & McNeel, D. G. Hum. Immunol. 71, 496–504 (2010).

    Article  CAS  Google Scholar 

  8. Beer, T. M. et al. J. Clin. Oncol. 35, 40–47 (2017).

    Article  CAS  Google Scholar 

  9. Antonarakis, E. S. et al. J. Clin. Oncol. 38, 395–405 (2020).

    Article  CAS  Google Scholar 

  10. Calcinotto, A. et al. Nature 559, 363–369 (2018).

    Article  CAS  Google Scholar 

  11. Rosenberg, S. A., Yang, J. C., White, D. E. & Steinberg, S. M. Ann. Surg. 228, 307–319 (1998).

    Article  CAS  Google Scholar 

  12. Atkins, M. B. et al. J. Clin. Oncol. 17, 2105–2116 (1999).

    Article  CAS  Google Scholar 

  13. Chamie, K. et al. J. Clin. Oncol. 39, 510 (2021).

    Article  Google Scholar 

  14. Khushalani, N. I. et al. Future Oncol. 16, 2165–2175 (2020).

    Article  CAS  Google Scholar 

  15. Xu, C. et al. Clin. Cancer Res. 23, 5869–5880 (2017).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Genitourinary Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA

    Ravi A. Madan

  2. Laboratory of Tumor Immunology and Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA

    Claudia Palena

Authors
  1. Ravi A. Madan
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Claudia Palena
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to Ravi A. Madan or Claudia Palena.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Madan, R.A., Palena, C. Behind the IL-8 ball in prostate cancer. Nat Cancer 2, 775–776 (2021). https://doi.org/10.1038/s43018-021-00235-3

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s43018-021-00235-3

Search

Advanced search

Quick links

Nature Briefing: Cancer

Sign up for the Nature Briefing: Cancer newsletter — what matters in cancer research, free to your inbox weekly.

Get what matters in cancer research, free to your inbox weekly. Sign up for Nature Briefing: Cancer