Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:


2-HG modulates glioma macrophages via Trp metabolism

Immuno-oncology approaches have shown little efficacy against high-grade glioma, a devastating manifestation of brain cancer. A new study now finds a metabolic vulnerability in IDH1-mutant glioma that can be targeted to reprogram tumor-infiltrating macrophages and create a tumor microenvironment that is more responsive to immune-checkpoint therapy.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: IDH1-mutant HGGs drive infiltrating monocyte-derived macrophages to a tolerogenic phenotype via activation of the AhR signaling pathway.


  1. Yan, H. et al. N. Engl. J. Med. 360, 765–773 (2009).

    Article  CAS  Google Scholar 

  2. Dang, L. et al. Nature 462, 739–744 (2009).

    Article  CAS  Google Scholar 

  3. Chowdhury, R. et al. EMBO Rep. 12, 463–469 (2011).

    Article  CAS  Google Scholar 

  4. Lu, C. et al. Nature 483, 474–478 (2012).

    Article  CAS  Google Scholar 

  5. Klemm, F. et al. Cell 181, 1643–1660.e1617 (2020).

    Article  CAS  Google Scholar 

  6. Kohanbash, G. et al. J. Clin. Invest. 127, 1425–1437 (2017).

    Article  Google Scholar 

  7. Friedrich, M. et al. Nat. Cancer (2021).

  8. Guo, X., Pan, Y. & Gutmann, D. H. Neuro-oncol. 21, 1250–1262 (2019).

    Article  CAS  Google Scholar 

  9. Shinde, R. & McGaha, T. L. Trends Immunol. 39, 1005–1020 (2018).

    Article  CAS  Google Scholar 

  10. Shinde, R. et al. Nat. Immunol. 19, 571–582 (2018).

    Article  CAS  Google Scholar 

  11. McGaha, T. L. et al. Immunol. Rev. 249, 135–157 (2012).

    Article  CAS  Google Scholar 

  12. Rothhammer, V. et al. Nature 557, 724–728 (2018).

    Article  CAS  Google Scholar 

  13. Thackray, S. J., Mowat, C. G. & Chapman, S. K. Biochem. Soc. Trans. 36, 1120–1123 (2008).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Tracy L. McGaha.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Halaby, M.J., McGaha, T.L. 2-HG modulates glioma macrophages via Trp metabolism. Nat Cancer 2, 677–679 (2021).

Download citation

  • Published:

  • Issue Date:

  • DOI:

This article is cited by


Quick links

Nature Briefing: Cancer

Sign up for the Nature Briefing: Cancer newsletter — what matters in cancer research, free to your inbox weekly.

Get what matters in cancer research, free to your inbox weekly. Sign up for Nature Briefing: Cancer