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A Wnt twist in FTO’s role in cancer progression

FTO, an m6A RNA demethylase, is known mainly as an oncoprotein in various cancer types. FTO is now shown to act as a cancer suppressor in a subset of epithelial tumors through an interplay between epithelial-to-mesenchymal transition and Wnt signaling.

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Fig. 1: FTO acts as a tumor suppressor in diverse epithelial cancers.


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Correspondence to Hani Goodarzi.

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Navickas, A., Goodarzi, H. A Wnt twist in FTO’s role in cancer progression. Nat Cancer 2, 579–580 (2021).

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