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  • Clinical Outlook
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Finding the positive in triple-negative breast cancer

The treatment of triple-negative breast cancer remains chemotherapy based and lacks targeted drugs. However, immunotherapy combinations have shown promising activity, targeted chemotherapy options via antibody–drug conjugates are in the clinic, and molecular means of identifying targetable subsets are on the horizon. This Clinical Outlook discusses current and future possibilities for treating triple-negative breast cancer.

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Fig. 1: Treatment for mTNBC in the current state and in a potential future state.

References

  1. Hoadley, K. A. et al. Cell 173, 291–304.e296 (2018).

    Article  CAS  Google Scholar 

  2. Ring, B. Z. et al. BMC Cancer 16, 143 (2016).

    Article  Google Scholar 

  3. Burstein, M. D. et al. Clin. Cancer Res. 21, 1688–1698 (2015).

    Article  CAS  Google Scholar 

  4. Siegel, M. B. et al. J. Clin. Invest. 128, 1371–1383 (2018).

    Article  Google Scholar 

  5. Tutt, A. et al. Nat. Med. 24, 628–637 (2018).

    Article  CAS  Google Scholar 

  6. Bardia, A. et al. N. Engl. J. Med. 380, 741–751 (2019).

    Article  CAS  Google Scholar 

  7. Tung, N. M. et al. J. Clin. Oncol. 38, 4274–4282 (2020).

    Article  CAS  Google Scholar 

  8. Schmid, P. et al. N. Engl. J. Med. 379, 2108–2121 (2018).

    Article  CAS  Google Scholar 

  9. Cortes, J. et al. Lancet 396, 1817–1828 (2020).

    Article  Google Scholar 

  10. Carey, L. A. et al. J. Clin. Oncol. 30, 2615–2623 (2012).

    Article  CAS  Google Scholar 

  11. Zawistowski, J. S. et al. Cancer Discov. 7, 302–321 (2017).

    Article  CAS  Google Scholar 

  12. Voorwerk, L. et al. Nat. Med. 25, 920–928 (2019).

    Article  CAS  Google Scholar 

  13. Mittendorf, E. A. et al. Lancet 396, 1090–1100 (2020).

    Article  CAS  Google Scholar 

  14. Schmid, P. et al. N. Engl. J. Med. 382, 810–821 (2020).

    Article  CAS  Google Scholar 

Download references

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Correspondence to Lisa A. Carey.

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Carey, L.A. Finding the positive in triple-negative breast cancer. Nat Cancer 2, 476–478 (2021). https://doi.org/10.1038/s43018-021-00211-x

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