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Fatty acid synthesis enables brain metastasis

Cancer cells need to adapt their metabolic state to different microenvironments, particularly during metastatic spread, when they are exposed to the circulatory system as well as the distant organ. Two studies now show that upregulation of fatty acid synthesis is required for the formation of breast cancer metastasis in the lipid-poor environment of the brain.

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Fig. 1: Upregulation of de novo fatty acid synthesis via FASN enables HER2+ breast cancer cells to grow in the lipid-deprived microenvironment of the brain.


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Correspondence to Almut Schulze.

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Vogel, F.C.E., Schulze, A. Fatty acid synthesis enables brain metastasis. Nat Cancer 2, 374–376 (2021).

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