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Melanoma-reactive T cells take up residence

Shedding light on the mechanisms that underlie a durable response to immunotherapy, a recent study evaluating long-term survivors of melanoma treated with immunotherapy finds that tumor-associated T cell clonotypes are sustained over years and persist as expanded, cytokine IFN-γ–expressing resident memory T cells in the skin, with effector memory counterparts in the blood.

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Fig. 1: Clonally related, tumor-reactive T cells in patients with melanoma persist over time and in different compartments.


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A.-P.G. is funded by US National Institutes of Health K08 (5K08CA230164-03).

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Correspondence to Christian H. H. Ottensmeier.

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The authors declare no competing interests.

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Ganesan, AP., Ottensmeier, C.H.H. Melanoma-reactive T cells take up residence. Nat Cancer 2, 253–255 (2021).

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