Extended Data Fig. 1: Comparison of size, zeta potential, RNA encapsulation efficiency, and morphology for the nanoparticles. | Nature Cancer

Extended Data Fig. 1: Comparison of size, zeta potential, RNA encapsulation efficiency, and morphology for the nanoparticles.

From: Multifunctional oncolytic nanoparticles deliver self-replicating IL-12 RNA to eliminate established tumors and prime systemic immunity

Extended Data Fig. 1

a, b, Mean diameter (a) (nm) and Zeta potential (b) (mv) of different nanoparticles with or without encapsulation of replicon RNA. Shown are mean (box) of three different measurements from one of two independent experiments. (c) RNA encapsulation efficiency of DOTAP, Lipofectamine, and TT3 nanoparticles. Shown are mean (box) of 3 different measurements from one of two independent experiments. n.d. means non-detectable. dg, morphologies of DOTAP and TT3 lipid nanoparticles without (d, f) or with replicon RNA (e, g) were imaged by Cryo-TEM. Shown are representative images from one of three independent fields of view in a single experiment. Scale bar (100 nm) is indicated. The source data are provided with this paper; the source data for dg are also stored at https://doi.org/10.6084/m9.figshare.12498047.

Source data

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