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TNF-shaped microbiota promotes cancer

The approval of anti-TNF therapy for colitis over 20 years ago represented a paradigm shift for the treatment of this disease. Anti-TNF therapy is now shown to prevent colitis-associated colon cancer in mice by modifying the gut microbiota composition and transcriptional activity, including genes in Escherichia coli that control colibactin synthesis.

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Fig. 1: Anti-TNF prevents colon cancer development by modifying the composition and transcriptional activity of the gut microbiota in two mouse models of colitis-associated colon carcinogenesis.


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Correspondence to Giorgio Trinchieri.

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Trinchieri, G. TNF-shaped microbiota promotes cancer. Nat Cancer 1, 667–669 (2020).

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