Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Microbiome

TNF-shaped microbiota promotes cancer

The approval of anti-TNF therapy for colitis over 20 years ago represented a paradigm shift for the treatment of this disease. Anti-TNF therapy is now shown to prevent colitis-associated colon cancer in mice by modifying the gut microbiota composition and transcriptional activity, including genes in Escherichia coli that control colibactin synthesis.

This is a preview of subscription content

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Fig. 1: Anti-TNF prevents colon cancer development by modifying the composition and transcriptional activity of the gut microbiota in two mouse models of colitis-associated colon carcinogenesis.

References

  1. 1.

    Pouillon, L., Travis, S., Bossuyt, P., Danese, S. & Peyrin-Biroulet, L. Nat. Rev. Gastroenterol. Hepatol. 17, 365–376 (2020).

    Article  Google Scholar 

  2. 2.

    Brennan, C. A. & Garrett, W. S. Annu. Rev. Microbiol. 70, 395–411 (2016).

    CAS  Article  Google Scholar 

  3. 3.

    Moutinho, B. D., de Barros, J. R., Baima, J. P., Saad-Hossne, R. & Sassaki, L. Y. Am. J. Case Rep. 21, e920949 (2020).

    Article  Google Scholar 

  4. 4.

    Popivanova, B. K. et al. J. Clin. Invest. 118, 560–570 (2008).

    CAS  PubMed  PubMed Central  Google Scholar 

  5. 5.

    Drewes, J. L. et al. NPJ Biofilms Microbiomes 3, 34 (2017).

    Article  Google Scholar 

  6. 6.

    Wirbel, J. et al. Nat. Med. 25, 679–689 (2019).

    CAS  Article  Google Scholar 

  7. 7.

    Carlson, E. S. & Balskus, E. P. Nat. Chem. 11, 867–869 (2019).

    CAS  Article  Google Scholar 

  8. 8.

    Arthur, J. C. et al. Science 338, 120–123 (2012).

    CAS  Article  Google Scholar 

  9. 9.

    Pleguezuelos-Manzano, C. et al. Nature 580, 269–273 (2020).

    CAS  Article  Google Scholar 

  10. 10.

    Wilson, M. R. et al. Science 363, eaar7785 (2019).

    CAS  Article  Google Scholar 

  11. 11.

    Yang, y, Gharaibeh, R. Z., Newsome, R. C. & Jobin, C. Nat. Cancer https://doi.org/10.1038/s43018-020-0078-7 (2020).

    Article  Google Scholar 

  12. 12.

    Martin, P. et al. PLoS Pathog. 9, e1003437 (2013).

    CAS  Article  Google Scholar 

  13. 13.

    Lee, J. H. et al. Am. J. Respir. Crit. Care Med. 168, 1462–1470 (2003).

    Article  Google Scholar 

  14. 14.

    Dejea, C. M. et al. Science 359, 592–597 (2018).

    CAS  Article  Google Scholar 

  15. 15.

    Tomasetti, C., Marchionni, L., Nowak, M. A., Parmigiani, G. & Vogelstein, B. Proc. Natl Acad. Sci. USA 112, 118–123 (2015).

    CAS  Article  Google Scholar 

Download references

Author information

Affiliations

Authors

Corresponding author

Correspondence to Giorgio Trinchieri.

Ethics declarations

Competing interests

The author declares no competing interests.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Trinchieri, G. TNF-shaped microbiota promotes cancer. Nat Cancer 1, 667–669 (2020). https://doi.org/10.1038/s43018-020-0090-y

Download citation

Search

Quick links