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TUMOR IMMUNOLOGY

Immunoediting of cancer metastasis by NK cells

Natural killer (NK) cells serve a critical role in the control of metastasis. NK cells are now shown to preferentially control monoclonal metastases derived from single circulating tumor cells rather than polyclonal metastases derived from cell clusters. These findings provide further evidence that NK cells are linked to metastatic cell immunoediting.

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Fig. 1: NK cell immunoediting of circulating tumor cells.

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Correspondence to Mark J. Smyth.

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Nakamura, K., Smyth, M.J. Immunoediting of cancer metastasis by NK cells. Nat Cancer 1, 670–671 (2020). https://doi.org/10.1038/s43018-020-0081-z

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