LUNG CANCER

Keap1ing an eye on Slc33A1

KEAP1 is a tumor suppressor encoded by a gene commonly mutated in lung cancer. A systematic search for Keap1-mutant cancer vulnerabilities now reveals that Slc33a1 is a context-specific essential gene that represents a promising new anti-cancer target.

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Fig. 1: Targeting KEAP1-mutant lung cancer.

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Correspondence to Luke A. Gilbert.

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Gilbert, L.A. Keap1ing an eye on Slc33A1. Nat Cancer 1, 575–576 (2020). https://doi.org/10.1038/s43018-020-0072-0

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