Studies of the tumor microenvironment have provided fundamental insights into cancer progression. A new study now delineates the dynamics of immune-cell alterations at the single-cell level and across stages of multiple myeloma, elucidating the microenvironmental changes involved in the precursor states of the disease.
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Cross center single-cell RNA sequencing study of the immune microenvironment in rapid progressing multiple myeloma
npj Genomic Medicine Open Access 26 January 2023
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Z.Z. is a founder of Analytical BioSciences, received research grants from Amgen, Bayer and Boehringer Ingelheim, and is a consultant for InnoCare Pharma.
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Zhang, Q., Zhang, Z. Stepwise immune alterations in multiple myeloma progression. Nat Cancer 1, 477–479 (2020). https://doi.org/10.1038/s43018-020-0063-1