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Microbiome genomics for cancer prediction

Although cancer genomics is a powerful tool to understand cancer and develop diagnostic tools, the contribution of the microbiome in cancer diagnosis and clinical assessment is much less studied. Elinav, Greten and colleagues provide their respective views on how studying cancer metagenomes could facilitate identification, diagnosis and staging of different tumor types.

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Fig. 1: Microbial DNA signatures from tissue and blood to classify cancer.

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Acknowledgements

L.A. received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska‐Curie Grant Agreement No. 842203. E.E. is the incumbent of the Sir Marc and Lady Tania Feldmann Professorial Chair, a senior fellow at the Canadian Institute of Advanced Research (CIFAR) and an international scholar at the Bill & Melinda Gates Foundation and the Howard Hughes Medical Institute. T.F.G. is supported by the Intramural Research Program of the NIH, NCI (ZIA BC 011344).

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Correspondence to Eran Elinav or Tim F. Greten.

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E.E. is a scientific consultant for DayTwo and BiomX.

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Adlung, L., Elinav, E., Greten, T.F. et al. Microbiome genomics for cancer prediction. Nat Cancer 1, 379–381 (2020). https://doi.org/10.1038/s43018-020-0059-x

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