CANCER MODELS

The therapy escapes of small-cell lung cancer

Small-cell lung cancer rapidly develops resistance to standard-of-care therapy. Two papers now establish xenograft models derived from patient-derived circulating tumor cells and show that initially homogeneous, chemoresponsive tumors rapidly recur as heterogeneous drug-refractory disease.

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Fig. 1: Modeling SCLC response to therapy using single-cell sequencing and patient-derived CDXs.

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Correspondence to Anton Berns.

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Berns, A. The therapy escapes of small-cell lung cancer. Nat Cancer 1, 374–375 (2020). https://doi.org/10.1038/s43018-020-0058-y

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