The therapy escapes of small-cell lung cancer

Small-cell lung cancer rapidly develops resistance to standard-of-care therapy. Two papers now establish xenograft models derived from patient-derived circulating tumor cells and show that initially homogeneous, chemoresponsive tumors rapidly recur as heterogeneous drug-refractory disease.

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Fig. 1: Modeling SCLC response to therapy using single-cell sequencing and patient-derived CDXs.


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Correspondence to Anton Berns.

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Berns, A. The therapy escapes of small-cell lung cancer. Nat Cancer 1, 374–375 (2020).

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