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TUMOR IMMUNOLOGY

Carpet-bombing tumors with IFN-γ

Nature Cancer volume 1, pages 270–272 (2020)Cite this article

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To demonstrate the long-range effects of CD8+ T cell–secreted interferon-γ on bystander tumor cells, two studies now use mosaic models of antigen loss in tumors combined with intravital imaging. Factors that influence the length scale of diffusible signals could shape disease progression in cancer and autoimmunity.

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Fig. 1: IFN-γ secreted by activated CD8+ T cells exerts long-range bystander effects in the tumor microenvironment.

References

  1. Alspach, E., Lussier, D. M. & Schreiber, R. D. Cold Spring Harb. Perspect. Biol. https://doi.org/10.1101/cshperspect.a028480 (2019).

    Article  PubMed  Google Scholar 

  2. Hoekstra, M. E., Bornes, L., Dijkgraaf, F. E., Philips, D. & Pardieck, I. N. Nat. Cancer https://doi.org/10.1038/s43018-020-0036-4 (2020).

  3. Thibaut, R. et al. Nat. Cancer https://doi.org/10.1038/s43018-020-0038-2 (2020).

  4. Huse, M., Lillemeier, B. F., Kuhns, M. S., Chen, D. S. & Davis, M. M. Nat. Immunol. 7, 247–255 (2006).

    Article  CAS  Google Scholar 

  5. Sanderson, N. S. R. et al. Proc. Natl Acad. Sci. USA 109, 7835–7840 (2012).

    Article  CAS  Google Scholar 

  6. Perona-Wright, G., Mohrs, K. & Mohrs, M. Nat. Immunol. 11, 520–526 (2010).

    Article  CAS  Google Scholar 

  7. Müller, A. J. et al. Immunity 37, 147–157 (2012).

    Article  Google Scholar 

  8. Zhang, B., Karrison, T., Rowley, D. A. & Schreiber, H. J. Clin. Invest. 118, 1398–1404 (2008).

    Article  CAS  Google Scholar 

  9. Ross, A. E. & Pompano, R. R. Anal. Chim. Acta 1000, 205–213 (2018).

    Article  CAS  Google Scholar 

  10. Mojic, M., Takeda, K. & Hayakawa, Y. Int. J. Mol. Sci. 19, 1–13 (2018).

    Google Scholar 

  11. Yeku, O. O. & Brentjens, R. J. Biochem. Soc. Trans. 44, 412–418 (2016).

    Article  CAS  Google Scholar 

  12. Oyler-Yaniv, J. et al. Mol. Cell 66, 635–647.e7 (2017).

    Article  CAS  Google Scholar 

  13. Gordon-Alonso, M., Hirsch, T., Wildmann, C. & Van Der Bruggen, P. Nat. Commun. 8, 1–15 (2017).

    Article  CAS  Google Scholar 

  14. Ståhl, P. L. et al. Science 35, 78–82 (2016).

    Article  Google Scholar 

  15. Rodriques, S. G. et al. Science 363, 1463–1467 (2019).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Department of Pathology and ImmunoX, University of California, San Francisco, San Francisco, CA, USA

    Kenneth H. Hu & Matthew F. Krummel

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  1. Kenneth H. Hu
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  2. Matthew F. Krummel
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Correspondence to Matthew F. Krummel.

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The authors declare no competing interests.

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Hu, K.H., Krummel, M.F. Carpet-bombing tumors with IFN-γ. Nat Cancer 1, 270–272 (2020). https://doi.org/10.1038/s43018-020-0042-6

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