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Mapping cell phenotypes in breast cancer

Tumor heterogeneity remains an obstacle to effective clinical management of breast cancer. Two new studies use high-dimensional imaging of single-cell protein expression in situ in clinical samples to link genomic alterations to multi-cellular features of the tumor microenvironment and reveal breast-cancer phenotypes associated with clinical outcome.

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Fig. 1: High dimensional imaging analysis of breast cancer.

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Correspondence to Michael Angelo.

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Keren, L., Angelo, M. Mapping cell phenotypes in breast cancer. Nat Cancer 1, 156–157 (2020). https://doi.org/10.1038/s43018-020-0031-9

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