a, Box-and-whisker plot of the distribution of SMA expression by stromal cell types (n = 141, 818 cells). Boxes represent the interquartile range. Lines dividing boxes indicate the median, and vertical lines represent range of expression from the 1st to 99th percentile. b, Pathway enrichment analysis of genes (hypergeometric test; adjusted for multiple comparisons) linked to miRNAs positively correlated with myofibroblast and vascular smooth muscle cell proportions (n = 371 tumours; related to Fig. 4).