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How to kill Treg cells for immunotherapy

Achieving depletion of regulatory T cells while sparing tumor-specific effector T cells has long remained an elusive goal of immunotherapy. A new study describing the development of an antibody to the cytokine receptor CD25 optimized to ensure depletion of regulatory T cells without blocking binding of the cytokine IL-2 will reinvigorate interest in this therapeutic avenue.

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Fig. 1: Anti-CD25NIB depletes organisms of Treg cells to enhance tumor killing.


  1. Sakaguchi, S., Sakaguchi, N., Asano, M., Itoh, M. & Toda, M. J. Immunol. 155, 1151–1164 (1995).

    CAS  PubMed  Google Scholar 

  2. Onizuka, S. et al. Cancer Res. 59, 3128–3133 (1999).

    CAS  PubMed  Google Scholar 

  3. Woo, E. Y. et al. J. Immunol. 168, 4272–4276 (2002).

    Article  CAS  Google Scholar 

  4. Shang, B., Liu, Y., Jiang, S. J. & Liu, Y. Sci. Rep. 5, 15179 (2015).

    Article  CAS  Google Scholar 

  5. Solomon, I. et al. Nat. Cancer (2020).

  6. Jacobs, J. F. et al. Clin. Cancer Res. 16, 5067–5078 (2010).

    Article  CAS  Google Scholar 

  7. Rech, A. J. et al. Sci. Transl. Med. 4, 134ra162 (2012).

    Article  Google Scholar 

  8. Thornton, A. M. & Shevach, E. M. J. Exp. Med. 188, 287–296 (1998).

    Article  CAS  Google Scholar 

  9. Arce Vargas, F. et al. Immunity 46, 577–586 (2017).

    Article  CAS  Google Scholar 

  10. van Elsas, A., Hurwitz, A. A. & Allison, J. P. J. Exp. Med. 190, 355–366 (1999).

    Article  Google Scholar 

  11. Suntharalingam, G. et al. N. Engl. J. Med. 355, 1018–1028 (2006).

    Article  CAS  Google Scholar 

  12. Loskog, A. et al. Leukemia 20, 1819–1828 (2006).

    Article  CAS  Google Scholar 

  13. Rafiq, S. et al. Nat. Biotechnol. 36, 847–856 (2018).

    Article  CAS  Google Scholar 

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Correspondence to James L. Riley.

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Ellis, G.I., Riley, J.L. How to kill Treg cells for immunotherapy. Nat Cancer 1, 1134–1135 (2020).

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