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Mutagenic exposures shape immunotherapy responses

The response to immunotherapy has been linked to human leukocyte antigen (HLA) genotype in certain cancers. A new study examining the interaction between cancer type–specific mutational exposures and the B44 and B27 HLA supertypes finds that patients with mutant peptides complementary to these supertypes receive the most benefit from immune-checkpoint blockade.

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Fig. 1: Charged HLA-B supertypes bind mutant proteins for which specific tumor types are enriched.


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Correspondence to Hannah Carter.

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Castro, A., Carter, H. Mutagenic exposures shape immunotherapy responses. Nat Cancer 1, 1132–1133 (2020).

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