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Mutagenic exposures shape immunotherapy responses

The response to immunotherapy has been linked to human leukocyte antigen (HLA) genotype in certain cancers. A new study examining the interaction between cancer type–specific mutational exposures and the B44 and B27 HLA supertypes finds that patients with mutant peptides complementary to these supertypes receive the most benefit from immune-checkpoint blockade.

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Fig. 1: Charged HLA-B supertypes bind mutant proteins for which specific tumor types are enriched.


  1. Schumacher, T. N., Scheper, W. & Kvistborg, P. Annu. Rev. Immunol. 37, 173–200 (2019).

    Article  CAS  Google Scholar 

  2. Vinay, D. S. et al. Semin. Cancer Biol. 35, S185–S198 (2015).

    Article  Google Scholar 

  3. Chowell, D. et al. Science 359, 582–587 (2018).

    Article  CAS  Google Scholar 

  4. Arora, S. et al. Adv. Ther. 36, 2638–2678 (2019).

    Article  Google Scholar 

  5. Sidney, J., Peters, B., Frahm, N., Brander, C. & Sette, A. BMC Immunol. 9, 1 (2008).

    Article  Google Scholar 

  6. McGranahan, N. et al. Cell 171, 1259–1271.e11 (2017).

    Article  CAS  Google Scholar 

  7. Alexandrov, L. B. et al. Nature 500, 415–421 (2013).

    Article  CAS  Google Scholar 

  8. Alexandrov, L. B. et al. Science 354, 618–622 (2016).

    Article  CAS  Google Scholar 

  9. Cummings, A. L. et al. Nat. Cancer (2020).

    Article  Google Scholar 

  10. Negrao, M. V. et al. J. Thorac. Oncol. 14, 1021–1031 (2019).

    Article  CAS  Google Scholar 

  11. Capietto, A.-H. et al. J. Exp. Med. 217, e20190179 (2020).

    Article  Google Scholar 

  12. Pham, T. V. et al. Mol. Oncol. 14, 1680–1694 (2020).

    Article  CAS  Google Scholar 

  13. Wood, M. A., Weeder, B. R., David, J. K., Nellore, A. & Thompson, R. F. Genome Med. 12, 33 (2020).

    Article  CAS  Google Scholar 

  14. Cabrera, T. et al. Hum. Immunol. 64, 941–950 (2003).

    Article  CAS  Google Scholar 

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Correspondence to Hannah Carter.

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Castro, A., Carter, H. Mutagenic exposures shape immunotherapy responses. Nat Cancer 1, 1132–1133 (2020).

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