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ISACs take a Toll on tumors

Immunostimulatory agents such as Toll-like receptor (TLR) agonists have shown promising antitumor efficacy but are associated with therapy-related toxicities when delivered systemically. Immune-stimulating antibody conjugates are now shown to deliver TLR agonists with potent preclinical antitumor activities.

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Fig. 1: ISACs: two hits against cancer with one antibody.


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Correspondence to Olivier Demaria.

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O.D. and E.V. are employees of Innate Pharma.

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Demaria, O., Vivier, E. ISACs take a Toll on tumors. Nat Cancer 2, 12–13 (2021).

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