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A nano-engager for iNKT cells in cancer

Invariant natural killer T cells (iNKT cells) are innate-like CD1d-restricted T cells that have NK cell–like properties and bear an invariant T cell receptor (iTCR). iNKT cells have shown potential for cancer immunotherapy. A study now shows that stabilization of the iTCR–CD1d complex via a single-chain bi-specific antibody stimulates iNKT cell–mediated anti-tumor immunity.

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Fig. 1: iNKT cell–related therapies.


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Correspondence to Mark A. Exley or Richard S. Blumberg.

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Competing interests

M.A.E. is employed by Imvax, a cancer vaccine–based company, and acts as consultant for Agentus, a company developing iNKT cell–based therapies.

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Exley, M.A., Gensollen, T. & Blumberg, R.S. A nano-engager for iNKT cells in cancer. Nat Cancer 1, 1032–1034 (2020).

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